A train suffered partial damage in the blast, while 10 vehicles parked in the area were also damaged, police said. The impact of the explosion shattered the windows and glass panels of nearby buildings.
Following the incident, an emergency was declared in government hospitals across Quetta, with doctors and medical staff summoned to handle the situation.
Railway authorities said the Peshawar-bound Jaffar Express was stopped at Quetta Railway Station after the blast as a precautionary measure.
Babar Yousafzai, the spokesperson to the home minister, said that all relevant institutions have been placed on high alert following an explosion in the city.
He urged the public not to gather near the blast site to ensure safety and allow emergency teams to carry out rescue operations without obstruction.